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Combinational effect of intestinal and hepatic CYP3A5 genotypes on tacrolimus pharmacokinetics in recipients of living donor liver transplantation

机译：肠道和肝CYP3A5基因型对活体肝移植受者的肠和肝CYP3A5基因型基因型的组合作用

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摘要

BackgroundFor living donor liver transplantation, the genetic association of CYP3A5 genotype of recipient's native intestine and donor's liver allograft with tacrolimus pharmacokinetics has not been explained completely considering liver regeneration time. The goal of study was to investigate the longitudinal effects of recipient-donor combinational CYP3A5 genotypes on tacrolimus dose-normalized concentration (C/D ratio) in blood.

机译：背景对于活体供体肝移植，尚未完全解释考虑到肝再生时间的原因，CYP3A5基因型与受体天然肠和供体肝同种异体移植物与他克莫司的药代动力学之间的遗传联系。研究的目的是研究受体-供体联合CYP3A5基因型对他克莫司剂量标准化浓度（C / D比）的纵向影响。

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期刊名称 other
作者
Eunhee Ji; Leena Choi; Kyung-Suk Suh; Joo-Youn Cho; Nayoung Han; Jung Mi Oh;
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作者单位

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年(卷),期 -1(94),8
年度 -1
页码 866–872
总页数 14
原文格式 PDF
正文语种
中图分类
关键词
tacrolimus living donor liver transplantation CYP3A5 donor recipient;

机译：他克莫司;活体供肝移植;CYP3A5;供体;受体;

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专利

1. Combinational effect of intestinal and hepatic CYP3A5 genotypes on tacrolimus pharmacokinetics in recipients of living donor liver transplantation [J] . JiE., ChoiL., SuhK.-S., Transplantation: Official Journal of the Transplantation Society . 2012,第8期

机译：肠道和肝脏CYP3A5基因型对活供体肝移植受者他克莫司药代动力学的组合影响
2. Impact of Donor and Recipient CYP3A5*3 Genotype on Tacrolimus Population Pharmacokinetics in Chinese Adult Liver Transplant Recipients [J] . Shao Jia, Wang Chenyu, Fu Peng, The annals of pharmacotherapy . 2020,第7期

机译：供体和受体CYP3A5 * 3基因型对中国成人肝脏移植受者的巨粒种群药代动力学的影响
3. A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype [J] . Kotaro Itohara, Ikuko Yano, Tetsunori Tsuzuki, CPT: Pharmacometrics & Systems Pharmacology . 2019,第8期

机译：肝脏肝移植中的躯干司的最小生理学药代理模型：肝再生与细胞色素P450 3A5（CYP3A5）基因型相关的透视图
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

机译：CYP3A4 * 18B多态性与中国肾移植患者滑石M药代动力学的关系
5. Pharmacokinetics of intraarterial calcineurin inhibitor delivery to composite tissue: A study of regional and systemic advantages of intraarterial delivery of calcineurin inhibitors (cyclosporine and tacrolimus) to a vascularly isolated rabbit forelimb. [D] . Shirbacheh, Mansour V. 1999

机译：动脉钙调神经磷酸酶抑制剂向复合组织递送的药代动力学：钙调神经磷酸酶抑制剂（环孢素和他克莫司）向血管分离的兔前肢的动脉内递送的区域和全身优势的研究。
6. A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype [O] . Kotaro Itohara, Ikuko Yano, Tetsunori Tsuzuki, 2019

机译：他克莫司在活体供体肝移植中的最小生理基础药代动力学模型：与肝脏再生和细胞色素P450 3A5（CYP3A5）基因型相关的观点
7. Combinational Effect of Intestinal and Hepatic CYP3A5 Genotypes on Tacrolimus Pharmacokinetics in Recipients of Living Donor Liver Transplantation [O] . Eunhee Ji, Leena Choi, Kyung-Suk Suh, 2012

机译：肠道和肝CYP3A5基因型对活体肝移植受者的肠和肝CYP3A5基因型基因型的组合作用

Combinational effect of intestinal and hepatic CYP3A5 genotypes on tacrolimus pharmacokinetics in recipients of living donor liver transplantation

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