EXPRESSION OF SOLUBLE ADENYLYL CYCLASE (sAC) IN LENTIGO MALIGNA: USE OF IMMUNOHISTOCHEMISTRY WITH anti-sAC ANTIBODY (R21) IN DIAGNOSIS OF LENTIGO MALIGNA AND ASSESMENT OF MARGINS

摘要

BackgroundSoluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate (cAMP), a signaling molecule involved in regulating melanocyte differentiation, proliferation and melanogenesis. R21, a mouse monoclonal antibody against sAC, shows a pattern of pan nuclear staining in lentigo maligna showing possible utility for diagnosis and for margin assessment.