Judge Jury and Executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control

摘要

In this issue of Molecular Cell, describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping and 5′-3′ exoribonucease activity, and functions as an important checkpoint in co-transcriptional capping of RNA polymerase II (pol II) pre-mRNA transcripts.