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Risk of venous thromboembolism associated with single and combinedeffects of Factor V Leiden Prothrombin 20210A and Methylenetethraydrofolatereductase C677T: a meta-analysis involving over 11000 cases and 21000controls

机译：单发和合并静脉血栓栓塞的风险因子V Leiden凝血酶原20210A和亚甲基四氢叶酸的作用还原酶C677T：荟萃分析涉及超过11000例和21000例控制项

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BACKGROUNDGenetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden,FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies.

机译：背景技术遗传因素和环境因素在确定静脉血栓栓塞（VTE）的风险中相互作用。在许多研究中已经研究了与因子V多态变异体G1691A（因子V Leiden，FVL），凝血酶原的G20210A（PT20210A）和亚甲基四氢叶酸还原酶（C677T MTHFR）基因的C677T相关的风险。

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期刊名称 other
作者
B Simone; V De Stefano; E Leoncini; J Zacho; I Martinelli; J Emmerich; E Rossi; AR Folsom; WY Almawi; PY Scarabin; M den Heijer; M Cushman; S Penco; A Vaya; P Angchaisuksiri; G Okumus; D Gemmati; S Cima; N Akar; KI Oguzulgen; V Ducros; C Lichy; C Fernandez-Miranda; A Szczeklik; JA Nieto; JD Torres; V Le Cam-Duchez; P Ivanov; C Cantu; VM Shmeleva; M Stegnar; D Ogunyemi; SS Eid; N Nicolotti; E De Feo; W Ricciardi; S Boccia;
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年(卷),期 -1(28),8
年度 -1
页码 621–647
总页数 39
原文格式 PDF
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Venous thromboembolism genetic susceptibility Factor V Leiden Prothrombin G202010A Methylentetrahydrofolate reductase C677T;

机译：静脉血栓栓塞;遗传易感性;因子V莱顿;凝血酶原G202010A;甲基四氢叶酸还原酶C677T;

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1. Risk of venous thromboembolism associated with single and combined effects of Factor v Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: A meta-analysis involving over 11,000 cases and 21,000 controls [J] . SimoneB., DeStefanoV., LeonciniE., European journal of epidemiology . 2013,第8期

机译：与因子v Leiden，凝血酶原20210A和亚甲基四氢叶酸还原酶C677T的单一或联合作用相关的静脉血栓栓塞风险：一项涉及11,000例病例和21,000例对照的荟萃分析
2. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. [J] . Emmerich J, Rosendaal FR, Cattaneo M, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2001,第3期

机译：因子V莱顿和凝血酶原20210A对静脉血栓栓塞风险的综合影响-对8例病例对照研究的合并分析，包括2310例病例和3204例对照。静脉血栓栓塞合并分析研究组。
3. Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210A/A prothrombin mutation and heterozygous 1691G/A factor V Leiden mutation. [J] . Halbmayer WM, Kalhs T, Haushofer A, Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis . 1999,第5期

机译：兄弟姐妹中年轻时的静脉血栓栓塞与纯合的20210A / A凝血酶原突变和杂合的1691G / A因子V Leiden突变同时存在。
4. Ontology-based Venous Thromboembolism Risk Factors Mining and Model Developing from Medical Records [C] . Yuqing Yang, Xin Wang, Yu Huang, IEEE International Conference on Bioinformatics and Biomedicine . 2018

机译：基于本体的病历静脉血栓栓塞危险因素挖掘与模型开发
5. Risk factors for clinical manifestation in carriers of Factor V Leiden and prothrombin gene mutations. [D] . De Sancho, Maria. 2009

机译：因子V Leiden和凝血酶原基因突变携带者临床表现的危险因素。
6. Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type [O] . Birgitte F. Sode, Kristine H. Allin, Morten Dahl, 2013

机译：与V因子Leiden和凝血酶原突变以及血型相关的静脉血栓栓塞和心肌梗塞的风险
7. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls [O] . Simone, Benedetto, De Stefano, E, Leoncini, Emanuele, 2013

机译：与因子V Leiden，凝血酶原20210A和亚甲基四氢叶酸还原酶C677T的单一和联合作用相关的静脉血栓栓塞风险：一项涉及11,000例病例和21,000例对照的荟萃分析

Risk of venous thromboembolism associated with single and combinedeffects of Factor V Leiden Prothrombin 20210A and Methylenetethraydrofolatereductase C677T: a meta-analysis involving over 11000 cases and 21000controls

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