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Phase 1 Trial of Temsirolimus in Combination with Irinotecan and Temozolomide in Children Adolescents and Young Adults with Relapsed or Refractory Solid Tumors: A Children’s Oncology Group Study

机译：替莫罗莫司与伊立替康和替莫唑胺合用在儿童青少年和年轻成人复发或难治性实体瘤中的第一阶段试验：儿童肿瘤学小组研究

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BackgroundmTOR inhibitors have activity in pediatric tumor models. A phase I trial of the mTOR inhibitor temsirolimus (TEM) with irinotecan (IRN) and temozolomide (TMZ) was conducted in children with recurrent/refractory solid tumors, including central nervous system (CNS) tumors.

机译：BackgroundmTOR抑制剂在小儿肿瘤模型中具有活性。 mTOR抑制剂西罗莫司（TEM）与伊立替康（IRN）和替莫唑胺（TMZ）的I期试验在患有中枢神经系统（CNS）肿瘤的复发/难治性实体瘤患儿中进行。

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期刊名称 other
作者
R Bagatell; RE Norris; AM Ingle; CH Ahern; S Voss; E Fox; A Little; B Weigel; PC Adamson; SM Blaney;
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作者单位

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年(卷),期 -1(61),5
年度 -1
页码 833–839
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
Phase 1 solid tumors temsirolimus;

机译：第1期;实体瘤;西罗莫司;

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1. Phase 1 Trial of Temsirolimus in Combination with Irinotecan and Temozolomide in Children, Adolescents and Young Adults with Relapsed or Refractory Solid Tumors: A Children's Oncology Group Study [J] . Bagatell Rochelle, Norris Robin, Ingle Ashish M., Pediatric blood & cancer . 2014,第5期

机译：替莫罗莫司与伊立替康和替莫唑胺联用在儿童，青少年和年轻成人复发或难治性实体瘤中的一期试验：儿童肿瘤学组研究
2. Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with relapsed or refractory solid tumors: a Children's Oncology Group phase I consortium study. [J] . Wagner LM, Perentesis JP, Reid JM, Pediatric blood & cancer . 2010,第4期

机译：一期的长春新碱，口服伊立替康和替莫唑胺（VOIT）两种方案用于复发或难治性实体瘤儿童的一期临床试验：儿童肿瘤学小组一期财团研究。
3. Phase 2 Trial of Cixutumumab in Children, Adolescents, and Young Adults With Refractory Solid Tumors: A Report From the Children's Oncology Group [J] . Weigel Brenda, Malempati Suman, Reid Joel M., Pediatric blood & cancer . 2014,第3期

机译：西妥木单抗在儿童，青少年和难治性实体瘤成人中的2期试验：儿童肿瘤学组的报告
4. Mobi-Expo: Using software modified smartphortes to characterize mobile phone use in children, adolescents, and young adults [C] . Mobi-Expo study group Annual conference of the International Society of Exposure Science . 2014

机译：Mobi-Expo：使用经过软件修改的智能手机来表征儿童，青少年和年轻人中的手机使用情况
5. A phase I study of vincristine, escalating doses of irinotecan, temozolomide and bevacizumab (VIT-B) in pediatric and adolescent patients with recurrent or refractory solid tumors of non-hematopoietic origin [D] . Venkatramani, Rajkumar. 2010

机译：长春新碱，伊非替康，替莫唑胺和贝伐单抗（VIT-B）逐步剂量在患有非造血源性复发或难治性实体瘤的儿童和青少年患者中的I期研究
6. Phase I Trial of Two Schedules of Vincristine Oral Irinotecan and Temozolomide (VOIT) for Children with Relapsed or Refractory Solid Tumors: A Childrens Oncology Group Phase I Consortium Study [O] . Lars M. Wagner, John P. Perentesis, Joel M. Reid, -1

机译：阶段I对复发或难治性实体瘤的儿童进行两次长春酮口服伊替康和替替莫替昔粒剂（voit）的试验：儿童肿瘤学阶段I联盟研究
7. Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group [O] . Brenda Weigel, Suman Malempati, Joel M. Reid, 2013

机译：儿童，青少年和难治性实体肿瘤的儿童，青少年和年轻成年人的阶段2试验：儿童肿瘤学群的报告

Phase 1 Trial of Temsirolimus in Combination with Irinotecan and Temozolomide in Children Adolescents and Young Adults with Relapsed or Refractory Solid Tumors: A Children’s Oncology Group Study

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