Distribution Transition and Thermodynamic Stability of Protein Conformations in the Denaturant-Induced Unfolding of Proteins

摘要

BackgroundExtensive and intensive studies on the unfolding of proteins require appropriate theoretical model and parameter to clearly illustrate the feature and characteristic of the unfolding system. Over the past several decades, four approaches have been proposed to describe the interaction between proteins and denaturants, but some ambiguity and deviations usually occur in the explanation of the experimental data.