Mean Magnetic Susceptibility Regularized Susceptibility Tensor Imaging (MMSR-STI) for Estimating Orientations of White Matter Fibers in Human Brain

摘要

PurposeThere is an increasing number of studies showing that magnetic susceptibility in white matter fibers is anisotropic and may be described by a tensor. However, the limited head rotation possible for in vivo human studies leads to an ill-conditioned inverse problem in susceptibility tensor imaging (STI). Here we suggest combined use of limiting the susceptibility anisotropy to white matter and imposing morphology constraints on the mean magnetic susceptibility (MMS) for regularizing the STI inverse problem.