Real-Time Pre-Treatment Review Limits Unacceptable Deviations on a Cooperative Group Radiotherapy Technique Trial: Quality Assurance Results of RTOG 0933

摘要

Purpose/ObjectivesRTOG 0933 was a phase II trial of hippocampal avoidance during whole-brain radiotherapy for patients with brain metastases. Results demonstrated improvement in short-term memory decline, as compared to historical controls, and preservation of quality of life. Integral to the conduct of this trial were quality assurance processes inclusive of pre-enrollment credentialing and pre-treatment centralized review of enrolled cases.