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Flexible and modular MPI simulation framework and its use in modelling a μMPI

机译:灵活的模块化MPI仿真框架及其在μMPI建模中的用途

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摘要

The availability of thorough system simulations for detailed and accurate performance prediction and optimization of existing and future designs for a new modality such as magnetic particle imaging (MPI) are very important. Our framework aims to simulate a complete MPI system by providing a description of all (drive and receive) coils, permanent magnet configurations, magnetic nanoparticle (MNP) distributions, and characteristics of the signal processing chain. The simulation is performed on a user defined spatial and temporal discrete grid. The magnetization of the MNP is modelled by either the Langevin theory or as ideal particles with infinite steepness and ideal saturation. The magnetic fields are approximated in first order by calculating the Biot-Savart integral. Additionally the coupling constants between the excitation coils (e.g. drive field coils) and the receive coils can be determined. All coils can be described by an XML description language based on primitive geometric shapes. First simulations of a modelled μMPI system are shown. In this regard μMPI refers to a small one dimensional system for samples of a size of a few tens of a cubic millimeter and a spatial resolution of about 200 μm.
机译:对于详细而准确的性能预测以及针对新模式(例如磁粉成像(MPI))的现有和将来设计的优化,全面的系统仿真的可用性非常重要。我们的框架旨在通过提供所有(驱动和接收)线圈,永磁体配置,磁性纳米粒子(MNP)分布以及信号处理链特征的描述来模拟完整的MPI系统。模拟是在用户定义的空间和时间离散网格上执行的。 MNP的磁化可以通过Langevin理论建模,也可以将其建模为具有无限陡度和理想饱和度的理想粒子。通过计算Biot-Savart积分可以一阶估算磁场。另外,可以确定励磁线圈(例如驱动场线圈)和接收线圈之间的耦合常数。可以使用基于原始几何形状的XML描述语言来描述所有线圈。显示了建模的μMPI系统的第一个模拟。就这一点而言,μMPI指的是一个小的一维系统,用于样本大小为几十立方毫米,空间分辨率约为200μm的样本。

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