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Predictors of Exceptional Longevity: Effects of Early-Life and Midlife Conditions and Familial Longevity

机译:超常寿命的预测因素:早期寿命和中年状况以及家族寿命的影响

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摘要

Knowledge of strong predictors of mortality and longevity is very important for actuarial science and practice. Earlier studies found that parental characteristics as well as early-life conditions and midlife environment play a significant role in survival to advanced ages. However, little is known about the simultaneous effects of these three factors on longevity. This ongoing study attempts to fill this gap by comparing centenarians born in the United States in 1890–1891 with peers born in the same years who died at age 65. The records for centenarians and controls were taken from computerized family histories, which were then linked to 1900 and 1930 U.S. censuses. As a result of this linkage procedure, 765 records of confirmed centenarians and 783 records of controls were obtained. Analysis with multivariate logistic regression found the existence of both general and gender-specific predictors of human longevity. General predictors common for men and women are paternal and maternal longevity. Gender-specific predictors of male longevity are occupation as a farmer at age 40, Northeastern region of birth in the United States, and birth in the second half of year. A gender-specific predictor of female longevity is the availability of radio in the household according to the 1930 U.S. census. Given the importance of familial longevity as an independent predictor of survival to advanced ages, we conducted a comparative study of biological and nonbiological relatives of centenarians using a larger sample of 1,945 validated U.S. centenarians born in 1880–1895. We found that male gender of centenarian has a significant positive effect on survival of adult male relatives (brothers and fathers) but not female blood relatives. Life span of centenarian siblings-in-law is lower compared to life span of centenarian siblings and does not depend on centenarian gender. Wives of male centenarians (who share lifestyle and living conditions) have a significantly better survival compared to wives of centenarians’ brothers. This finding demonstrates an important role of shared familial environment and lifestyle in human longevity. The results of this study suggest that familial background, some early-life conditions and midlife characteristics play an important role in longevity.
机译:了解死亡率和寿命的强预测因素对于精算科学和实践非常重要。较早的研究发现,父母的特征以及早年的生活条件和中年的环境在高龄生存中起着重要作用。但是,关于这三个因素对寿命的同时影响知之甚少。这项正在进行的研究试图通过比较1890年至1891年在美国出生的百岁老人与在65岁时去世的同年出生的同龄人之间的差异来填补这一空白。百岁老人和控制者的记录取自计算机化的家庭历史,然后将其联系起来到1900年和1930年的美国人口普查。通过此链接过程,获得了765条已确认的百岁老人的记录和783条对照的记录。用多元逻辑回归分析发现,人类寿命的一般和性别预测因子均存在。男女共同的总预测指标是父母和母亲的寿命。性别有关男性寿命的预测因素是在美国东北部出生的40岁和下半年出生的农民中的职业。根据1930年的美国人口普查,女性寿命的性别预测指标是家庭中是否可以使用收音机。考虑到家族长寿作为高龄生存率的独立预测指标的重要性,我们进行了一项对百岁老人的生物学和非生物学亲戚的比较研究,使用了1880年至1895年出生的1,945名经过验证的美国百岁老人的较大样本。我们发现,百岁老人的男性性别对成年男性亲戚(兄弟和父亲)的存活率有显着的积极影响,但对女性血统亲属的存活率没有显着影响。与百岁老人的兄弟姐妹的寿命相比,百岁arian的兄弟姐妹的寿命较低,并且不依赖于百岁老人的性别。与百岁老人的兄弟的妻子相比,男性百岁老人的妻子(具有共同的生活方式和生活条件)的存活率要好得多。这一发现证明了共同的家庭环境和生活方式在人类长寿中的重要作用。这项研究的结果表明,家族背景,一些早期生活状况和中年特征对延年益寿起着重要作用。

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