Highly-accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling

摘要

PurposeIn clinical studies compartmental average CEST measurements rather than high-resolution CEST images may suffice for evaluating its diagnostic value. A recently-developed method—spectroscopy with linear algebraic modeling or SLAM—could directly provide compartmental measures with dramatically reduced scan time and optimal signal-to-noise ratios. Here, we test whether SLAM can be adapted to significantly accelerate CEST acquisitions.