Fine-Mapping of QT Regions in Global Populations Refines Previously Identified QT Loci and Identifies Signals Unique to African and Hispanic Descent Populations

摘要

BackgroundThe electrocardiographically measured QT interval (QT) is heritable and its prolongation is an established risk factor for several cardiovascular diseases. Yet, most QT genetic studies have been performed in European ancestral populations, possibly reducing their global relevance.