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Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans Mice and Farm Animals

机译:脂肪库的分子异质性-对人类小鼠和农场动物脂肪-肌肉交叉谈话的潜在影响

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摘要

Adipose tissue is considered as a major endocrine organ that secretes numerous proteins called adipokines. The heterogeneous nature of adipose tissue in different parts of the body suggests respective heterogeneity of proteomes and secretomes. This review consolidates knowledge from recent studies targeting the diversity of different adipose depots affecting the pattern of secreted adipokines and discusses potential consequences for the cross-talk between adipose and skeletal muscle in humans, rodent models and farm animals. Special attention is paid to muscle-associated fat depots like inter- and intramuscular fat that become focus of attention in the context of the rather new notion of skeletal muscle as a major endocrine organ. Understanding the complexity of communication between adipocytes and skeletal muscle cells will allow developing strategies for improvement of human health and for sustainable production of high quality meat.
机译:脂肪组织被认为是一种主要的内分泌器官,它分泌许多称为脂肪因子的蛋白质。人体不同部位的脂肪组织具有异质性,提示蛋白质组和分泌组分别具有异质性。这篇综述巩固了近期研究的知识,这些研究针对影响分泌性脂肪因子模式的不同脂肪库的多样性,并讨论了人类,啮齿动物模型和农场动物中脂肪与骨骼肌之间串扰的潜在后果。在骨骼肌作为主要的内分泌器官这一新概念的背景下,应特别注意与肌肉相关的脂肪库,例如肌肉间和肌肉内的脂肪,这些已成为关注的焦点。了解脂肪细胞和骨骼肌细胞之间通信的复杂性将允许制定改善人类健康和可持续生产优质肉的策略。

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