Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age Hippocampal atrophy and White Matter Hyperintensities

摘要

Background and PurposeInterpreting the clinical significance of moderate-to-severe global cerebral atrophy (GCA) is a conundrum for many clinicians, who visually interpret brain imaging studies in routine clinical practice. GCA may be attributed to normal aging, Alzheimer’s disease (AD), or cerebrovascular disease (CVD). Understanding the relationships of GCA with aging, AD, and CVD is important for accurate diagnosis and treatment decisions for cognitive complaints.