A neural biomarker the error-related negativity predicts the first onset of generalized anxiety disorder in a large sample of adolescent females

摘要

ObjectiveAn increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error-related negativity is an event-related potential elicited when people make mistakes on simple laboratory-based reaction time tasks that has been associated with risk for anxiety. The present study examined whether the error-related negativity prospectively predicted the first onset of generalized anxiety disorder (GAD) over 1.5 years in adolescent girls.