Simultaneous spectrophotometric determination of paracetamol phenylephrine and chlropheniramine in pharmaceuticals using chemometric approaches

摘要

Background and the purpose of the studyThe linear multivariate calibration models such as principal components regression (PCR) and partial least squares regressions (PLS1 and PLS2) due to the mathematical simplicity and physical or chemical interpretability are sufficient and generally preferred method for analysis of multicomponent drugs. In this study, simultaneous determination of paracetamol, phenylephrine and chlorpheniramine in pharmaceuticals using chemometric methods and UV spectrophotometry is reported as a simple alternative technique.