Decreased expression of 14-3-3 σ an early event of malignant transformation of respiratory epithelium also facilitates progression of squamous cell lung cancer

摘要

BackgroundIt has been shown that 14-3-3 σ serves as a tumor suppressor gene, and is downregulated in various tumor tissues. However, the role of 14-3-3 σ during the initiation and progression of lung squamous cell carcinoma (SqCC) is not well understood.