Innate immunity and chronic rhinosinusitis: What we have learned from animal models

摘要

ObjectiveChronic rhinosinusitis (CRS) is a heterogeneous and multifactorial disease characterized by dysregulated inflammation. Abnormalities in innate immune function, including sinonasal epithelial cell barrier function, mucociliary clearance, response to pathogen‐associated molecular patterns (PAMPs) via pattern recognition receptors, and the contribution of innate immune cells, will be highlighted in this review.