Inositol 145‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation

摘要

BackgroundEndothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca²⁺ mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca²⁺ concentration in endothelial cells is able to induce endothelial NO synthase phosphorylation. Ca²⁺ release mediated by 3 subtypes of inositol 1,4,5‐trisphosphate receptors (IP 3Rs) from the endoplasmic reticulum and subsequent Ca²⁺ entry after endoplasmic reticulum Ca²⁺ store depletion has been proposed to be the major pathway to mobilize Ca²⁺ in endothelial cells. However, the physiological role of IP 3Rs in regulating blood pressure remains largely unclear.