Complex Role for E‐Prostanoid 4 Receptors in Hypertension

摘要

BackgroundProstaglandin E2 (PGE 2) is a major prostanoid with multiple actions that potentially affect blood pressure (BP). PGE 2 acts through 4 distinct E‐prostanoid (EP) receptor isoforms: EP1 to EP4. The EP4 receptor (EP4R) promotes PGE 2‐dependent vasodilation, but its role in the pathogenesis of hypertension is not clear.