首页> 美国卫生研究院文献>Open Forum Infectious Diseases >Switching Tenofovir/Emtricitabine/Efavirenz (TDF/FTC/EFV) to TDF/FTC/Rilpivirine vs Continuing TDF/FTC/EFV in HIV-Infected Patients With Virological Suppression: A Randomized Controlled Trial

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Switching Tenofovir/Emtricitabine/Efavirenz (TDF/FTC/EFV) to TDF/FTC/Rilpivirine vs Continuing TDF/FTC/EFV in HIV-Infected Patients With Virological Suppression: A Randomized Controlled Trial

机译：在病毒感染的HIV感染患者中将替诺福韦/恩曲他滨/依非韦伦（TDF / FTC / EFV）改为TDF / FTC / Rilpivirine与持续TDF / FTC / EFV相比：一项随机对照试验

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A randomized controlled noninferiority trial was conducted in HIV-infected patients receiving tenofovir/emtricitabine/efavirenz (TDF/FTC/EFV) with virological suppression in a resource-limited setting. Switching to TDF/FTC/rilpivirine was noninferior to continuing TDF/FTC/EFV in terms of maintaining compete viral suppression at 24 weeks and provided better lipid profiles and fewer central nervous system adverse effects.

机译：在资源受限的情况下，对接受替诺福韦/恩曲他滨/依非韦伦（TDF / FTC / EFV）并进行病毒学抑制的HIV感染患者进行了一项随机对照非劣效性试验。就维持24周竞争性病毒抑制作用而言，改用TDF / FTC /利比韦林不逊于持续的TDF / FTC / EFV，并提供了更好的脂质分布和更少的中枢神经系统不良反应。

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期刊名称 Open Forum Infectious Diseases
作者
Sirichai Wiriyatanakorn; Somnuek Sungkanuparph;
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作者单位

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年(卷),期 2019(6),7
年度 2019
页码 ofz297
总页数 4
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词
efavirenz rilpivirine switching antiretroviral therapy randomized controlled trial;

机译：efavirenz;rilpivirine;切换;抗逆转录病毒疗法;随机对照试验;

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1. Switching to coformulated rilpivirine ( RPV RPV ), emtricitabine ( FTC FTC ) and tenofovir alafenamide from either RPV RPV , FTC FTC and tenofovir disoproxil fumarate ( TDF TDF ) or efavirenz, FTC FTC and TDF TDF : 96‐week results from two randomized clinical trials [J] . Hagins D, Orkin C, Daar ES, HIV medicine . 2018,第10期

机译：从RPV RPV，FTC FTC和Tenofovir Disoproxil（TDF TDF）或Efavirenz，FTC FTC和TDF TDF中，切换到Coformulated毛柳胺（RPV RPV）和替诺福韦醛酰胺，FTC FTC，FTC FTC和TDF：来自两种随机临床试验的96周的结果
2. Efficacy and safety of emtricitabine/tenofovir alafenamide (FTC/TAF) vs. emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) as a backbone for treatment of HIV-1 infection in virologically suppressed adults: subgroup analysis by third agent of a randomized, double-blind, active-controlled phase 3 trial [J] . Post Frank A., Yazdanpanah Yazdan, Schembri Gabriel, HIV clinical trials . 2017,第3期

机译：Emtricicabine / Tenofovir Alafenaine（FTC / TAF）与Emtrickabine / Tenofovir Disoproxil umarate（FTC / TDF）作为用于治疗病毒学抑制成人的HIV-1感染的骨干的疗效和安全性：由随机的第三代理分析亚组分析 -blind，主动控制的第3阶段试验
3. Switching at Low HIV-1 RNA into Fixed Dose Combinations: TDF/FTC/RPV is non-inferior to TDF/FTC/EFV in first-line suppressed patients living with HIV [J] . Paula Munderi, Edwin Were, Anchalee Avihingsanon, Southern African journal of HIV medicine . 2019,第1期

机译：将低HIV-1 RNA切换成固定剂量组合：TDF / FTC / RPV在一线抑制患者的一线抑制患者中的TDF / FTC / RPV是非较差的TDF / FTC / EFV
4. Switching to coformulated rilpivirine (RPV) emtricitabine (FTC) and tenofovir alafenamide from either RPV FTC and tenofovir disoproxil fumarate (TDF) or efavirenz FTC and TDF: 96‐week results from two randomized clinical trials [O] . D Hagins, C Orkin, ES Daar, -1

机译：从RPVFTC和替诺福韦富马酸泰诺福韦酯（EFD）或依法韦韦富马酸（EFFARENZ）FTC和TDF改用共配制的rilpivirine（RPV）恩曲他滨（FTC）和Tenofovir alafenamide：两项随机临床试验的96周结果
5. Efficacy and safety of emtricitabine/tenofovir alafenamide (FTC/TAF) vs. emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) as a backbone for treatment of HIV-1 infection in virologically suppressed adults: subgroup analysis by third agent of a randomized, double-blind, active-controlled phase 3 trial [O] . Frank A. Post, Yazdan Yazdanpanah, Gabriel Schembri, 2017

机译：Emtricicabine / Tenofovir Alafenainide（FTC / TAF）与Emtricicabine / Tenofovir Disoproxil（FTC / TDF）作为治疗病毒学抑制成人HIV-1感染的骨干（FTC / TDF）的疗效和安全性：由随机的第三种试剂分析亚组分析-blind，主动控制的第3阶段试验

Switching Tenofovir/Emtricitabine/Efavirenz (TDF/FTC/EFV) to TDF/FTC/Rilpivirine vs Continuing TDF/FTC/EFV in HIV-Infected Patients With Virological Suppression: A Randomized Controlled Trial

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