The Relevance of Womens Diseases Jun Activation-domain Binding Protein 1 (JAB1) and p27kip1

摘要

The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27^kip1 are involved in the cell cycle. This is Jab1 and p27^kip1 interact with each other, Jab1 accelerate p27^kip1 from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27^kip1 is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27^kip1 were described in a recent article on the basis of relevant. Besides Jab1 and p27^kip1 will organize the relationship between the disease and women.