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Large-scale parallelization of nanomechanical mass spectrometry with weakly-coupled resonators

机译:具有弱耦合谐振器的纳米机械质谱的大规模并行化

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摘要

Nanomechanical mass spectrometry is a recent technological breakthrough that enables the real-time analysis of single molecules. In contraposition to its extreme mass sensitivity is a limited capture cross-section that can hinder measurements in a practical setting. Here we show that weak-coupling between devices in resonator arrays can be used in nanomechanical mass spectrometry to parallelize the measurement. This coupling gives rise to asymmetric amplitude peaks in the vibrational response of a single nanomechanical resonator of the array, which coincide with the natural frequencies of all other resonators in the same array. A rigorous theoretical model is derived that explains the physical mechanisms and describes the practical features of this parallelization. We demonstrate the significance of this parallelization through inertial imaging of analytes adsorbed to all resonators of an array, with the possibility of simultaneously detecting resonators placed at distances a hundred times larger than their own physical size.
机译:纳米机械质谱技术是一项最新技术突破,可对单个分子进行实时分析。与其极高的质量灵敏度相反,捕获截面有限,在实际环境中可能会阻碍测量。在这里,我们表明,谐振器阵列中器件之间的弱耦合可用于纳米机械质谱分析中以使测量并行化。这种耦合在阵列的单个纳米机械谐振器的振动响应中产生不对称的振幅峰值,该峰值与同一阵列中所有其他谐振器的固有频率一致。得出了一个严格的理论模型,该模型解释了物理机制并描述了这种并行化的实际功能。我们通过对吸附到阵列所有谐振器的分析物进行惯性成像来证明这种并行化的重要性,同时可以检测到距离比其自身物理尺寸大一百倍的谐振器。

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