An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol 14C-PEG-7 Phosphate

摘要

Background/AimsEstablishing dermal penetration rates is important to better understand the safety of topically applied materials, especially for premature infant skin with compromised skin barrier function. Skin prematurity involves thinner stratum corneum and underdeveloped epidermis/dermis resulting in decreased barrier function, higher transepidermal water loss and greater chemical penetration, when compared to healthy full-term neonate/adult skin.