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A boundary element model of the transport of a semi-infinite bubble through a microvessel bifurcation

机译:半无限大气泡通过微血管分叉传输的边界元模型

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摘要

Motivated by a developmental gas embolotherapy technique for selective occlusion of blood flow to tumors, we examined the transport of a pressure-driven semi-infinite bubble through a liquid-filled bifurcating channel. Homogeneity of bubble splitting as the bubble passes through a vessel bifurcation affects the degree to which the vascular network near the tumor can be uniformly occluded. The homogeneity of bubble splitting was found to increase with bubble driving pressure and to decrease with increased bifurcation angle. Viscous losses at the bifurcation were observed to affect the bubble speed significantly. The potential for oscillating bubble interfaces to induce flow recirculation and impart high stresses on the vessel endothelium was also observed.
机译:受用于选择性阻塞血液流向肿瘤的发展性气体栓塞治疗技术的推动,我们研究了压力驱动的半无限气泡通过充满液体的分叉通道的运输。当气泡通过血管分支时,气泡分裂的均匀性影响肿瘤附近血管网络被均匀阻塞的程度。发现气泡分裂的均匀性随着气泡驱动压力而增加,并且随着分叉角的增加而降低。观察到分叉处的粘性损失显着影响气泡速度。还观察到振荡气泡界面以引起流动再循环并在血管内皮上施加高应力的潜力。

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