Continuous 24-Hour Leptin Proopiomelanocortin and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin Soluble Leptin Receptor and Amino Acid Levels

摘要

Context:In order to characterize diurnal changes in central leptin and its target neuropeptide, proopiomelanocortin (POMC), we measured leptin and POMC in cerebrospinal fluid (CSF) as related to changes in plasma leptin and soluble leptin receptor (sOB-R) levels. CSF and plasma levels of 20 amino acids (AA) were also measured because AA can affect brain POMC.