>Motivation. The UMLS has been used in natural language processing applications such as information retrieval and information extraction systems. The mapping of free-text to UMLS concepts is important for these applications. To improve the mapping, we need a method to disambiguate terms that possess multiple UMLS concepts. In the general English domain, machine-learning techniques have been applied to sense-tagged corpora, in which senses (or concepts) of ambiguous terms have been annotated (mostly manually). Sense disambiguation classifiers are then derived to determine senses (or concepts) of those ambiguous terms automatically. However, manual annotation of a corpus is an expensive task. We propose an automatic method that constructs sense-tagged corpora for ambiguous terms in the UMLS using MEDLINE abstracts.>Methods. For a term W that represents multiple UMLS concepts, a collection of MEDLINE abstracts that contain W is extracted. For each abstract in the collection, occurrences of concepts that have relations with W as defined in the UMLS are automatically identified. A sense-tagged corpus, in which senses of W are annotated, is then derived based on those identified concepts. The method was evaluated on a set of 35 frequently occurring ambiguous biomedical abbreviations using a gold standard set that was automatically derived. The quality of the derived sense-tagged corpus was measured using precision and recall.>Results. The derived sense-tagged corpus had an overall precision of 92.9% and an overall recall of 47.4%. After removing rare senses and ignoring abbreviations with closely related senses, the overall precision was 96.8% and the overall recall was 50.6%.>Conclusions. UMLS conceptual relations and MEDLINE abstracts can be used to automatically acquire knowledge needed for resolving ambiguity when mapping free-text to UMLS concepts.
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