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Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969) a novel treatment for C. difficile infection

机译：ridinilazole（SMT19969）对艰难梭菌感染的新治疗方法对艰难梭菌毒素产生和细胞形态的影响

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ObjectivesRidinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial with activity against Clostridium difficile undergoing clinical trials. The purpose of this study was to assess the pharmacological activity of ridinilazole and assess the effects on cell morphology.

机译：目的雷地尼唑（SMT19969）是一种窄谱，不可吸收的抗菌剂，对艰难梭菌具有活性，正在接受临床试验。这项研究的目的是评估ridinilazole的药理活性，并评估其对细胞形态的影响。

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期刊名称 Journal of Antimicrobial Chemotherapy
作者
Eugénie Bassères; Bradley T. Endres; Mohammed Khaleduzzaman; Faranak Miraftabi; M. Jahangir Alam; Richard J. Vickers; Kevin W. Garey;
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年(卷),期 -1(71),5
年度 -1
页码 1245–1251
总页数 7
原文格式 PDF
正文语种
中图分类药学;微生物学;病毒传染病;
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专利

1. Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infection [J] . Basseres Eugenie, Endres Bradley T., Khaleduzzaman Mohammed, The Journal of Antimicrobial Chemotherapy . 2016,第5期

机译：ridinilazole（SMT19969）对艰难梭菌感染的新治疗方法对艰难梭菌毒素产生和细胞形态的影响
2. Evaluation of LIAISON? C. difficile glutamate dehydrogenase and LIAISON? C. difficile toxin A and B in Copan FecalSwabTM samples in a three-step algorithm for the diagnosis of Clostridium difficile infection [J] . Massimo Oggioni, Alessandra Bielli, Alice Nava, Microbiologia Medica . 2015,第1期

机译：评价LIAISON？艰难梭菌谷氨酸脱氢酶和LIAISON？采用三步法诊断Copan FecalSwabTM样品中的艰难梭菌毒素A和B，用于诊断艰难梭菌感染
3. Comparative performance of the GeneXpert C. difficile PCR assay and C. diff Quik Chek Complete kit assay for detection of Clostridium difficile antigen and toxins in symptomatic community-onset infections [J] . Wafaa Jamal, Eunice M. Pauline, Vincent O. Rotimi International journal of infectious diseases : . 2014,第Supplementa1期

机译：GeneXpert艰难梭菌PCR检测法和艰难梭菌完整试剂盒检测法在症状性社区发作感染中检测艰难梭菌抗原和毒素的比较性能
4. Development of a Vaccine Against Clostridium difficile Infection (CDI): Design, Purification, and Biological Activities of the Recombinant Toxin 1 Antigens [C] . Jerzy Karczewski Vaccine technology IV . 2012

机译：针对艰难梭菌感染（CDI）疫苗的开发：重组毒素1抗原的设计，纯化和生物活性。
5. Development of peptide inhibitors targeting Clostridium difficile toxins A/B and characterizing the regulatory role of a putative negative regulator TcdC in Clostridium difficile toxin gene expression. [D] . Abdeen, Sanofar J. 2013

机译：靶向艰难梭菌毒素A / B的肽抑制剂的开发以及表征推定的负调节剂TcdC在艰难梭菌毒素基因表达中的调节作用。
6. Antibodies to Recombinant Clostridium difficile Toxins A and B Are an Effective Treatment and Prevent Relapse of C. difficile-Associated Disease in a Hamster Model of Infection [O] . John A. Kink, Jim A. Williams 1998

机译：重组艰难梭菌毒素A和B的抗体在仓鼠感染模型中是有效的治疗和预防艰难梭菌相关疾病的复发
7. Evaluation of LIAISON® C. difficile glutamate dehydrogenase and LIAISON® C. difficile toxin A and B in Copan FecalSwabTM samples in a three-step algorithm for the diagnosis of Clostridium difficile infection [O] . Massimo Oggioni, Alessandra Bielli, Alice Nava, 2015

机译：在Copan FecalswabTm样品中评估LIaIsON®艰难梭菌谷氨酸脱氢酶和LIaIsON®艰难梭菌毒素a和B，采用三步法诊断艰难梭菌感染
8. Evaluation and Research on Antimicrobial Stewardship's Effect on Clostridium difficile (ERASE C. difficile) Project. Toolkit for Reduction of Clostridium difficile through Antimicrobial Stewardship. [R] . 2012

机译：抗菌药物管理对艰难梭菌（ERasE C. difficile）项目影响的评价与研究。通过抗菌药物管理减少艰难梭菌的工具包。

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Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969) a novel treatment for C. difficile infection

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