Genetic Susceptibility for Ischemic Infarction and Arteriolosclerosis based on Neuropathologic Evaluations

摘要

BackgroundRecent genetic studies of stroke and related risk factors have identified a growing number of susceptibility loci; however, the relationship of these alleles to ischemic stroke is unknown. The challenge in finding reproducible loci of ischemic stroke susceptibility may be in part related to the etiologic heterogeneity in clinically-defined stroke subtypes. In this study, we tested whether known single nucleotide polymorphisms (SNPs) associated with stroke or putative stroke risk factors are associated with neuropathologically-defined micro- or macroscopic infarcts and with arteriolosclerosis.