Early Change in Stroke Size Performs Best in Predicting Response to Therapy

摘要

BackgroundReliable imaging biomarkers of response to therapy in acute stroke are needed. Final infarct volume and percent early reperfusion have been used for this purpose. Early fluctuation in stroke size is a recognized phenomenon, but its utility as a biomarker for response to therapy has not been established. This study examined the clinical relevance of early change in stroke volume comparing it with final infarct volume and percent of early reperfusion in identifying early neurologic improvement (ENI).