Frequency and risk factors for cerebral arterial disease in a HIV/AIDS neuroimaging cohort

摘要

BackgroundInfection with HIV predisposes patients to a myriad of neurologic disorders, including cerebrovascular disease. The pathophysiology is likely multifactorial, with proposed mechanisms including infectious vasculitis, HIV-induced endothelial dysfunction, and adverse effects of combination antiretroviral therapy (cART). Epidemiologic data on clinically-evident cerebral vasculopathy in HIV-infected adults is scarce, even though stroke hospitalizations are rising in this patient population.