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The association between metal allergy total hip arthroplasty and revision

机译:金属过敏全髋关节置换术和翻修之间的关联

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摘要

>Background and purpose It has been speculated that the prevalence of metal allergy may be higher in patients with implant failure. We compared the prevalence and cause of revisions following total hip arthroplasty (THA) in dermatitis patients suspected to have contact allergy and in patients in general with THA. Furthermore, we compared the prevalence of metal allergy in dermatitis patients with and without THA.>Materials and methods The Danish Hip Arthroplasty Registry (DHAR) contained detailed information on 90,697 operations. The Gentofte patch-test database contained test results for patients suspected of having allergic contact dermatitis (n = 18,794). Cases (n = 356) were defined as patch-tested dermatitis patients who also had primary THA performed. Two age- and sex-matched controls (n = 712) from the patch-test database were sought for each case.>Results The prevalence of revision was similar in cases (12%) and in patients from the DHAR (13%). The prevalence of metal allergy was similar in cases and controls. However, the prevalence of metal allergy was lower in cases who were patch-tested after operation (6%) than in those who were patch-tested before operation (16%) (OR = 2.9; 95% CI = 1–8).>Interpretation We found that the risk of surgical revision was not increased in patients with metal allergies and that the risk of metal allergy was not increased in cases who were operated, in comparison to controls. Despite some important study limitations, our observations add to the evidence that the risk of complications in metal allergic patients seems limited.
机译:>背景和目的据推测,在植入失败的患者中,金属过敏的患病率可能更高。我们比较了全髋关节置换术(THA)在怀疑有接触过敏性皮炎患者和一般THA患者中发生率和翻修的原因。此外,我们比较了有和没有THA的皮炎患者中金属过敏的患病率。>材料和方法丹麦髋关节置换术注册(DHAR)包含90697例手术的详细信息。 Gentofte贴剂测试数据库包含怀疑患有过敏性接触性皮炎的患者的测试结果(n = 18,794)。病例(n = 356)被定义为也进行了原发性THA的斑贴试验性皮炎患者。每例病例均从补丁程序测试数据库中寻找了两个年龄和性别匹配的对照(n = 712)。>结果病例(12%)和患者的翻版患病率相似脱氢表雄酮(13%)。在病例和对照中,金属过敏的患病率相似。但是,金属过敏的患病率在手术后进行斑贴试验的患者(6%)比手术前进行斑贴试验的患者(16%)要低(OR = 2.9; 95%CI = 1-8)。 >解释我们发现,与对照组相比,金属过敏患者的手术翻修风险没有增加,并且手术病例中金属过敏的风险没有增加。尽管有一些重要的研究局限性,但我们的观察结果增加了证据,表明金属过敏患者发生并发症的风险似乎有限。

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