Vettumaran Gutika produced moderate CNS depressant effect, prolonged pentobarbitone and diazepam induced sleep, produced initial depression followed by stimulation of SMA in mice. It did not effect SCR and CAR in rats, reserpine effects in mice and threshold of tail-flick response in rats. It failed to protect rats and mice aginst Electro, pentylenetetrazol and strychnine induced convulsions and did not supress carrageenin induced hind paw oedema in rats. It produced negative inotropic and chronotropic effects on frog heart and antispasmodic effect in rats colon and guinea piga against various spasmogens. It depressed rhythmicity of rabbit jejunum and produced mild cholinolytic effect and has no effect on rat vasdeferens and frog rectus abdominis muscle.
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