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How to obtain and maintain favorable results after heart transplantation: keys to success?

机译:心脏移植后如何获得并保持良好的效果:成功的关键?

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摘要

We compared survival in our heart recipients with survival rates reported by the International Society of Heart and Lung Transplantation (ISHLT) Registry. As recipient and donor characteristics are changing over time, we studied four different eras. In order to differentiate between short- and long-term survival, we analyzed both overall survival and survival at one year. Obviously, this exercise is only relevant when baseline donor and recipient characteristics are comparable, as these differences may affect the outcome in opposite directions. To overcome this potential bias as much as possible, we calculated the Index for Mortality Prediction After Cardiac Transplantation (IMPACT)-scores and the Donor Risk Index (DRI). Looking to our results, we found that our DRIs in the different eras are almost equal to those obtained from the United Network for Organ Sharing database in the very same eras. Our IMPACT-scores, on the other hand, seem higher than those reported by ISHLT. Survival after transplantation and conditional on 1-year survival was higher than the outcome reported by the ISHLT Registry. As our operation technique and post-transplant immunosuppressive schedule did not differ from most centers, we speculated on potential factors that might contribute to our positive results. Patient selection and a relatively short waiting time are important contributors to the overall survival benefit. Our centralized follow-up may also have played an important role. Finally, the indefinite compulsory health insurance coverage in our country and easy access to different screening programs might also have influenced our outcome in a positive way. We are well aware that with challenges like donor organ shortage, more and more patients on mechanical circulatory support (MCS) will affect outcomes in the future.
机译:我们将心脏接受者的生存率与国际心脏和肺移植协会(ISHLT)注册处报告的生存率进行了比较。随着接受者和捐赠者的特征随时间变化,我们研究了四个不同的时代。为了区分短期和长期生存,我们分析了总体生存和一年生存。显然,此练习仅在基线供体和受体特征可比较时才有意义,因为这些差异可能会影响相反方向的结果。为了尽可能克服这种潜在的偏见,我们计算了心脏移植后死亡率预测指数(IMPACT)评分和供体风险指数(DRI)。根据我们的结果,我们发现不同时代的DRI几乎等于同一时代从美国器官共享网络联合数据库获得的DRI。另一方面,我们的IMPACT得分似乎高于ISHLT报告的得分。移植后的生存以及以一年生存为条件的生存率高于ISHLT注册中心报告的结果。由于我们的手术技术和移植后免疫抑制的时间表与大多数中心没有不同,因此我们推测了可能有助于我们取得积极成果的潜在因素。患者的选择和相对较短的等待时间是整体生存获益的重要因素。我们的集中后续行动也可能发挥了重要作用。最后,我国无限期的强制性健康保险覆盖面以及容易获得的不同筛查计划也可能以积极的方式影响了我们的结果。我们深知,由于供体器官短缺等挑战,越来越多的患者接受机械循环支持(MCS)将在未来影响结局。

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