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Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum

机译：等度高效液相色谱-紫外检测法同时测定人血清中伏立康唑和伊曲康唑及其羟基代谢物的含量

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摘要

A simple, specific method is presented for simultaneous determination of voriconazole and itraconazole and its metabolite, hydroxyitraconazole, in human serum using one-step liquid-liquid extraction and high-performance liquid chromatography. Linearity tests ranged from 0.1 to 8.0 μg/ml; the minimum detectable concentration was 0.03 μg/ml.

机译：提出了一种简单，特异性的方法，采用一步液-液萃取和高效液相色谱法同时测定人血清中的伏立康唑和伊曲康唑及其代谢物羟基伊曲康唑。线性测试范围为0.1至8.0μg/ ml；最低可检测浓度为0.03μg/ ml。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
GholamAli Khoschsorur; Franz Fruehwirth; Sieglinde Zelzer;
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作者单位

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年(卷),期 2005(49),8
年度 2005
页码 3569–3571
总页数 3
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum. [J] . Khoschsorur G, Fruehwirth F, Zelzer S Antimicrobial agents and chemotherapy. . 2005,第8期

机译：等度高效液相色谱-紫外检测法同时测定人血清中伏立康唑和伊曲康唑及其羟基代谢物的含量
2. Simultaneous determination of the azoles voriconazole, posaconazole, isavuconazole, itraconazole and its metabolite hydroxy-itraconazole in human plasma by reversed phase ultra-performance liquid chromatography with ultraviolet detection [J] . Verweij-van Wissen C.P.W.G.M., Burger D.M., Verweij P.E., Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2012,第Null期

机译：反相超高效液相色谱-紫外检测法同时测定人血浆中的唑类伏立康唑，泊沙康唑，伊沙康康唑，伊曲康唑及其代谢物羟基-伊曲康唑
3. Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum [J] . Mueller Carsten, Gehlen David, Blaich Cornelia, Therapeutic Drug Monitoring . 2017,第5期

机译：可靠且易于使用的液相色谱 - 串联质谱法，用于同时分析氟康唑，异甘油唑，伊唑唑，羟基丙基唑，甲酰基唑和人血清中的voriconazole
4. Determination of Phytosterols in Human Serum by High-performance Liquid Chromatography with Electrochemical Detection [C] . Nanako ITO, Hideki HAKAMATA, Fumiyo KUSU The Twelfth international symposium on electroanalytical chemistry : Program amp; extended abstracts . 2009

机译：高效液相色谱-电化学检测法测定人血清中的植物甾醇
5. Simultaneous Measurement of Carotenoids and Vitamins A and E in Human Serum by High Performance Liquid Chromatography (HLPC) and the Effect of Consuming Eggs on Serum Carotenoid and Lipid Concentrations and Macular Degeneration [D] . Aljohi, Hasan. 2013

机译：高效液相色谱（HLPC）同时测定人血清中的类胡萝卜素和维生素A和E，以及食用鸡蛋对血清类胡萝卜素和脂质浓度以及黄斑变性的影响
6. Comparison of High-Performance Liquid Chromatographic and Microbiological Methods for Determination of Voriconazole Levels in Plasma [O] . Sofia Perea, Gennethel J. Pennick, Asha Modak, 2000

机译：高效液相色谱法和微生物学方法测定血浆伏立康唑水平的比较
7. Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum [O] . Khoschsorur, GholamAli, Fruehwirth, Franz, Zelzer, Sieglinde 2005

机译：等度高效液相色谱-紫外检测法同时测定人血清中伏立康唑和伊曲康唑及其羟基代谢物的含量

Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum

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