Haemostatic chitosan coated gauze: in vitro interaction with human blood and in-vivo effectiveness

摘要

BackgroundChitosan and its derivates are widely used for biomedical application due to antioxidative, anti-inflammatory, antimicrobial and tissue repair induced properties. Chitosan-based materials also used as a haemostatic agent but influence of different molecular weight and concentration of chitosan on biological response of blood cells is still not clear.The aim of this research was to evaluate interaction between human blood cells and various forms of chitosan-based materials with different molecular weight and chitosan concentration and prove their effectiveness on in-vivo model.