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Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre open-label parralel-group phase II-III randomised superiority study (CAIRO6)

机译：HIPEC的围手术期全身治疗和细胞减灭术与单独使用HIPEC的前期细胞减灭术用于可切除的可切除结直肠腹膜转移：多中心开放标签平行治疗组II-III期随机优势研究（CAIRO6）

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BackgroundUpfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of perioperative systemic therapy to CRS-HIPEC improves oncological outcomes.

机译：背景技术HIPEC（CRS-HIPEC）进行的前期细胞还原手术是荷兰孤立的可切除结直肠腹膜转移瘤（PM）的标准治疗方法。这项研究调查了围手术期全身疗法添加到CRS-HIPEC是否可以改善肿瘤学结局。

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期刊名称 BMC Cancer
作者
Koen P. Rovers; Checca Bakkers; Geert A. A. M. Simkens; Jacobus W. A. Burger; Simon W. Nienhuijs; Geert-Jan M. Creemers; Anna M. J. Thijs; Alexandra R. M. Brandt-Kerkhof; Eva V. E. Madsen; Ninos Ayez; Nadine L. de Boer; Esther van Meerten; Jurriaan B. Tuynman; Miranda Kusters; Nina R. Sluiter; Henk M. W. Verheul; Hans J. van der Vliet; Marinus J. Wiezer; Djamila Boerma; Emma C. E. Wassenaar; Maartje Los; Cornelis B. Hunting; Arend G. J. Aalbers; Niels F. M. Kok; Koert F. D. Kuhlmann; Henk Boot; Myriam Chalabi; Schelto Kruijff; Lukas B. Been; Robert J. van Ginkel; Derk Jan A. de Groot; Rudolf S. N. Fehrmann; Johannes H. W. de Wilt; Andreas J. A. Bremers; Philip R. de Reuver; Sandra A. Radema; Karin H. Herbschleb; Wilhelmina M. U. van Grevenstein; Arjen J. Witkamp; Miriam Koopman; Nadia Haj Mohammad; Eino B. van Duyn; Walter J. B. Mastboom; Leonie J. M. Mekenkamp; Joost Nederend; Max J. Lahaye; Petur Snaebjornsson; Cornelis Verhoef; Hanneke W. M. van Laarhoven; Aeilko H. Zwinderman; Jeanette M. Bouma; Onno Kranenburg; Iris van ‘t Erve; Remond J. A. Fijneman; Marcel G. W. Dijkgraaf; Patrick H. J. Hemmer; Cornelis J. A. Punt; Pieter J. Tanis; Ignace H. J. T. de Hingh;
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年(卷),期 2019(19),-1
年度 2019
页码 390
总页数 15
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Colorectal neoplasms Peritoneal neoplasms Cytoreduction surgical procedures Hyperthermia induced Neoadjuvant therapy Adjuvant chemotherapy Bevacizumab Randomized controlled trial Mortality Progression-free survival;

机译：大肠肿瘤;腹膜肿瘤;细胞减少手术程序;热疗;诱导;新辅助治疗;辅助化疗;贝伐单抗;随机对照试验;死亡率;无进展生存;

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1. Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6) [J] . Koen P. Rovers, Dutch Peritoneal Oncology Group (DPOG), Checca Bakkers, BMC Cancer . 2019,第1期

机译：围手术期全身治疗和细胞功能性手术与Hipec与二期特单独分离的高度关头直肠腹膜转移的腹期细胞疗法术：多期一组，开放标签，平行组，第III期，随机，优势研究（开罗6）的协议
2. Colorectal Peritoneal Metastases Treated by Perioperative Systemic Chemotherapy and Cytoreductive Surgery With or Without Mitomycin C-Based HIPEC: A Comparative Study Using the Peritoneal Surface Disease Severity Score (PSDSS) [J] . Annals of surgical oncology . 2020,第1期

机译：通过围手术期全身化疗和细胞霉素治疗的结肠直肠腹膜转移，具有或不含丝霉素C基高度的，使用腹膜表面疾病严重程度评分（PSDS）进行比较研究
3. The treatment of peritoneal carcinomatosis of colorectal cancer with complete cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) with oxaliplatin: A belgian multicentre prospective phase II clinical study [J] . HompesD., DHooreA., VanCutsemE., Annals of surgical oncology . 2012,第7期

机译：奥沙利铂联合细胞减灭术和腹腔热化疗（HIPEC）对大肠癌腹膜癌的治疗：比利时多中心前瞻性II期临床研究
4. Protocol: Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from colorectal ovarian or gastric origin: protocol for a systematic review and individual participant data (IPD) meta-analyses of effectiveness and cost-effectiveness [O] . Kurinchi Gurusamy, Claire L Vale, Elena Pizzo, 2020

机译：方案：在结直肠卵巢或胃源性腹膜转移患者中采用高温术中腹膜化疗（HIPEC）相对于护理标准（SoC）进行细胞减灭术（CRS）：系统评价方案和个体参与者数据（IPD）荟萃分析和成本效益的关系
5. Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from colorectal, ovarian or gastric origin: protocol for a systematic review and individual participant data (IPD) meta-analyses of effectiveness and cost-effectiveness [O] . Kurinchi Gurusamy, Claire L Vale, Elena Pizzo, 2020

机译：具有高温术中腹膜化疗（HIPEC）与腹膜转移的高温术中腹膜化疗（HIPEC）的细胞功能性术治疗（HIPEC）与来自结肠癌，卵巢或胃源的腹膜转移：系统审查的议定书和个人参与者数据（IPD）的效果分析和成本效益

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre open-label parralel-group phase II-III randomised superiority study (CAIRO6)

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