Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation migration and invasion of neuroblastoma cell in a ligand dependent manner

摘要

BackgroundIt is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related cancer clinical specimens, moreover, the ectopic expression of ERα has been identified. However, the detailed function of ERα in the proliferation of neuroblastoma cell is yet unclear.