Potential of silver against human colon cancer: (synthesis characterization and crystal structures of xylyl (Ortho meta Para) linked bis-benzimidazolium salts and Ag(I)-NHC complexes: In vitro anticancer studies)

摘要

BackgroundSince the first successful synthesis of Ag(I)-N-heterocyclic carbene complex in 1993, this class of compounds has been extensively used for transmetallation reactions where the direct synthesis using other metal ions was either difficult or impossible. Initially, silver(I)-NHC complexes were tested for their catalytic potential but could not get fame because of lower potential compare to other competent compounds in this field; however, these compounds proved to have vital antimicrobial activities. These encouraging biomedical applications further convinced researchers to test these compounds against cancer. The current work has been carried out with this aim.