Prosecutor: parameter-free inference of gene function for prokaryotes using DNA microarray data genomic context and multiple gene annotation sources

摘要

BackgroundDespite a plethora of functional genomic efforts, the function of many genes in sequenced genomes remains unknown. The increasing amount of microarray data for many species allows employing the guilt-by-association principle to predict function on a large scale: genes exhibiting similar expression patterns are more likely to participate in shared biological processes.