Safety and immunogenicity of a freeze-dried Vero cell culture-derived inactivated Japanese encephalitis vaccine (KD-287 ENCEVAC®) versus a mouse brain-derived inactivated Japanese encephalitis vaccine in children: a phase III multicenter double-blinded randomized trial

摘要

BackgroundAlthough mouse brain-derived, inactivated Japanese encephalitis vaccines (JE-MBs) have been successfully used for a long time, potential rare neurological complications have prompted the development of a Vero cell culture-derived inactivated vaccine (JE-VC). In a phase III clinical study, we aimed to compare the safety and immunogenicity of a JE-VC, KD-287 with a JE-MB, JEV-GCC, in children.