The Dictyostelium discoideum homologue of Twinkle Twm1 is a mitochondrial DNA helicase an active primase and promotes mitochondrial DNA replication

摘要

BackgroundDNA replication requires contributions from various proteins, such as DNA helicases; in mitochondria Twinkle is important for maintaining and replicating mitochondrial DNA. Twinkle helicases are predicted to also possess primase activity, as has been shown in plants; however this activity appears to have been lost in metazoans. Given this, the study of Twinkle in other organisms is required to better understand the evolution of this family and the roles it performs within mitochondria.