The influence of cholinesterase inhibitor therapy for dementia on risk of cardiac pacemaker insertion: a retrospective population-based health administrative databases study in Ontario Canada

摘要

BackgroundCholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoing pacemaker insertion. Since these drugs have a marginal impact on patient outcomes, it might be preferable to change drug treatment rather than implant a pacemaker. This population-based study determined the association of people with dementia exposed to cholinesterase inhibitor medication and pacemaker insertion.