Mental state deterioration after switching from brand-name to generic olanzapine in an adolescent with bipolar affective disorder autism and intellectual disability: a case study

摘要

BackgroundThe appropriateness of use of generic instead of brand-name medication remains unresolved and controversial in several areas of medicine. Some evidence suggestive of variations in bioavailability and clinical effectiveness between different formulations make policy decisions occasionally difficult. The use of generic olanzapine is a widely acceptable practice on the basis of quality, safety and efficacy data and has been adopted in several countries.