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Spatially extended hybrid methods: a review

机译:空间扩展混合方法:综述

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摘要

Many biological and physical systems exhibit behaviour at multiple spatial, temporal or population scales. Multiscale processes provide challenges when they are to be simulated using numerical techniques. While coarser methods such as partial differential equations are typically fast to simulate, they lack the individual-level detail that may be required in regions of low concentration or small spatial scale. However, to simulate at such an individual level throughout a domain and in regions where concentrations are high can be computationally expensive. Spatially coupled hybrid methods provide a bridge, allowing for multiple representations of the same species in one spatial domain by partitioning space into distinct modelling subdomains. Over the past 20 years, such hybrid methods have risen to prominence, leading to what is now a very active research area across multiple disciplines including chemistry, physics and mathematics. There are three main motivations for undertaking this review. Firstly, we have collated a large number of spatially extended hybrid methods and presented them in a single coherent document, while comparing and contrasting them, so that anyone who requires a multiscale hybrid method will be able to find the most appropriate one for their need. Secondly, we have provided canonical examples with algorithms and accompanying code, serving to demonstrate how these types of methods work in practice. Finally, we have presented papers that employ these methods on real biological and physical problems, demonstrating their utility. We also consider some open research questions in the area of hybrid method development and the future directions for the field.
机译:许多生物和物理系统在多个空间,时间或人口规模上表现出行为。当要使用数值技术进行模拟时,多尺度过程会带来挑战。虽然较粗的方法(例如偏微分方程)通常可以快速模拟,但它们缺少在低浓度或小空间规模的区域中可能需要的单个级别的细节。但是,要在整个域和浓度较高的区域中以这种单独级别进行模拟,可能会导致计算量很大。空间耦合的混合方法提供了一个桥梁,通过将空间划分为不同的建模子域,可以在一个空间域中实现同一物种的多种表示。在过去的20年中,这种混合方法日益受到关注,这导致了如今在化学,物理和数学等多个学科领域非常活跃的研究领域。进行此审查有三个主要动机。首先,我们整理了大量的空间扩展混合方法,并将它们呈现在一个一致的文档中,同时将它们进行比较和对比,以便需要多尺度混合方法的任何人都可以找到最适合他们需要的方法。其次,我们提供了带有算法和随附代码的规范示例,以证明这些类型的方法在实践中如何工作。最后,我们提出了在实际生物学和物理问题上采用这些方法的论文,证明了它们的实用性。我们还考虑了在混合方法开发领域中的一些开放研究问题以及该领域的未来方向。

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