Cancer incidence in the Dalgety Bay area of Fife, Scotland, was examined following the detection of radium-226 particles by routine radiation monitoring. The study was confounded by rapid population growth, demographic change and the relatively high socioeconomic status of the Dalgety Bay population. Health Board Primary Care Division records were used to calculate population estimates and Carstairs deprivation score was used to adjust for socioeconomic characteristics. In the period 1975-90, 211 residents were registered as having cancer compared with 214.21 expected from Scottish national rates. Of specific cancers possibly associated with radiation, the incidence of stomach, liver, lung, bone, prostate, bladder and kidney cancer and lymphoma were lower than expected while colon, rectum, pancreas, skin, breast and thyroid cancer and multiple myeloma and leukaemia were higher. There were three cases of childhood leukaemia compared with 1.22 expected. The only statistically significant differences observed were for pancreas (11 cases, O/E 2.28), lung (25 cases, O/E 0.65) and non-melanoma skin (36 cases, O/E 1.50). Stomach cancer was of borderline statistical significance (four cases, O/E 0.40). Adjustments for socioeconomic factors accounted for the apparently low incidence of stomach and lung cancer and, to a lesser extent, skin cancer, which remained of borderline statistical significance. Results in relation to pancreas cancer were unchanged. The observations of raised incidence of pancreas and skin cancer arose in the context of a survey of 17 cancer sites, from which the finding of two or more statistically significant results is not unusual (P = 0.21), and the numbers of cases involved were small. The epidemiological evidence for an association between radiation exposure and pancreas cancer risk is weak. Stronger evidence exists for an association with skin cancer. In the present study the anatomical distribution of the 36 cases was similar to that found elsewhere in Scotland.
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机译：在通过常规辐射监测检测到镭226粒子之后，检查了苏格兰法夫郡达尔盖蒂湾地区的癌症发病率。该研究由于人口快速增长，人口变化和多尔盖蒂湾人口相对较高的社会经济地位而感到困惑。卫生局初级保健部门的记录用于计算人口估计数，Carstairs剥夺评分用于调整社会经济特征。在1975-90年期间，有211名居民被登记患有癌症，而根据苏格兰全国标准，预期为214.21。在可能与辐射有关的特定癌症中，胃癌，肝癌，肝癌，肺癌，肺癌，骨癌，前列腺癌，膀胱癌和肾癌和淋巴瘤的发生率低于预期，而结肠癌，直肠癌，胰腺癌，皮肤癌，乳腺癌和甲状腺癌以及多发性骨髓瘤和白血病则低于预期。更高。儿童白血病有3例，预期为1.22例。观察到的唯一具有统计学意义的差异是胰腺（11例，O / E 2.28），肺部（25例，O / E 0.65）和非黑素瘤皮肤（36例，O / E 1.50）。胃癌具有统计学意义（四例，O / E 0.40）。对社会经济因素的调整导致胃癌和肺癌的发生率明显较低，皮肤癌的发生率较低，这在统计学上仍具有临界意义。有关胰腺癌的结果未改变。在对17个癌症部位进行调查的背景下，出现了胰腺和皮肤癌发病率升高的观察结果，从中发现两个或多个具有统计学意义的显着结果并不罕见（P = 0.21），并且涉及的病例数很少。辐射暴露与胰腺癌风险之间相关性的流行病学证据微弱。存在与皮肤癌相关的更强有力的证据。在本研究中，这36例病例的解剖分布与苏格兰其他地方的解剖分布相似。
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