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Optimizing pharmacokinetic bridging studies in paediatric oncology using physiologically-based pharmacokinetic modelling: application to docetaxel

机译：使用基于生理的药物代谢动力学模型优化儿科肿瘤学中的药物代谢动力学桥接研究：在多西紫杉醇中的应用

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摘要

AimApplying physiologically-based pharmacokinetic (PBPK) modelling in paediatric cancer drug development is still challenging. We aimed to demonstrate how PBPK modelling can be applied to optimize dose and sampling times for a paediatric pharmacokinetic (PK) bridging study in oncology and to compare with the allometric scaling population PK (AS-popPK) approach, using docetaxel as an example.

机译：Aim在小儿癌症药物开发中应用基于生理的药代动力学（PBPK）模型仍然具有挑战性。我们旨在证明如何将PBPK模型应用于肿瘤学中的儿科药代动力学（PK）桥接研究的最佳剂量和采样时间，并以多西他赛为例，与异基因定标人群PK（AS-popPK）方法进行比较。

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期刊名称 British Journal of Clinical Pharmacology
作者
Hoai-Thu Thai; Florent Mazuir; Sylvaine Cartot-Cotton; Christine Veyrat-Follet;
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作者单位

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年(卷),期 2015(80),3
年度 2015
页码 534–547
总页数 14
原文格式 PDF
正文语种
中图分类药学;
关键词
docetaxel optimal design paediatrics physiologically-based pharmacokinetics;

机译：多西紫杉醇;最佳设计;儿科;基于生理的药代动力学;

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专利

1. Optimizing pharmacokinetic bridging studies in paediatric oncology using physiologically-based pharmacokinetic modelling: application to docetaxel [J] . Thai Hoai-Thu, Mazuir Florent, Cartot-Cotton Sylvaine, British Journal of Clinical Pharmacology . 2015,第3期

机译：使用基于生理的药物代谢动力学模型优化儿科肿瘤学中的药物代谢动力学桥接研究：在多西紫杉醇中的应用
2. Optimizing pharmacokinetic bridging studies in paediatric oncology using physiologically‐based pharmacokinetic modelling: application to docetaxel [J] . Thai Hoai‐Thu, Mazuir Florent, Cartot‐Cotton Sylvaine, British journal of clinical pharmacology . 2015,第3期

机译：使用基于生理的药物代谢动力学模型优化儿科肿瘤学中的药物代谢动力学桥接研究：在多西紫杉醇中的应用
3. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights [J] . Priyanka Arora, Gary Gudelsky, Pankaj B. Desai PLoS One . 2021,第4期

机译：Sprague-Dawley大鼠Letrozole脑和血浆药代动力学的基于性别的差异：应用基于生理学的药代动力学建模以获得定量见解
4. Simulated annealing in pharmacokinetic modeling of PET neuroreceptor studies: accuracy and precision compared with other optimization algorithms [C] . Yaqub M., Boellaard R., Kropholler M.A., Nuclear Science Symposium Conference Record, 2004 . 2004

机译：PET神经受体研究的药代动力学模型中的模拟退火：与其他优化算法相比的准确性和精密度
5. Applications of Physiologically Based Pharmacokinetic Modelling to Prediction of the Likelihood of Metabolic Drug Interactions in Paediatric Population and Studying Disparities in Pharmacokinetics Between Children and Adults [D] . Salem, Farzaneh. 2014

机译：基于生理的药代动力学模型在小儿人群中代谢药物相互作用的可能性预测和研究儿童与成人之间药代动力学差异的应用
6. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights [O] . Priyanka Arora, Gary Gudelsky, Pankaj B. Desai 2021

机译：Sprague-Dawley大鼠Letrozole脑和血浆药代动力学的基于性别的差异：基于生理学药代动力学建模的应用来获得定量洞察
7. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights [O] . Priyanka Arora, Gary Gudelsky, Pankaj B. Desai 2021

机译：Sprague-Dawley大鼠Letrozole脑和血浆药代动力学的基于性别的差异：基于生理学药代动力学建模的应用来获得定量洞察
8. Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling: Preliminary Evaluation and Case Study for the N-Methyl Carbamate Pesticides [R] . 2003

机译：基于生理学的药代动力学/药效学模型：N-甲基氨基甲酸酯类农药的初步评估和案例研究

Optimizing pharmacokinetic bridging studies in paediatric oncology using physiologically-based pharmacokinetic modelling: application to docetaxel

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