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美国卫生研究院文献>Brazilian Journal of Microbiology
>High occurrence of Fusobacterium nucleatum andClostridium difficile in the intestinal microbiota of colorectalcarcinoma patients
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High occurrence of Fusobacterium nucleatum andClostridium difficile in the intestinal microbiota of colorectalcarcinoma patients
Colorectal carcinoma is considered the fourth leading cause of cancer deaths worldwide. Several microorganisms have been associated with carcinogenesis, including Enterococcus spp., Helicobacter pylori, enterotoxigenic Bacteroides fragilis, pathogenic E. coli strains and oral Fusobacterium. Here we qualitatively and quantitatively evaluated the presence of oral and intestinal microorganisms in the fecal microbiota of colorectal cancer patients and healthy controls. Seventeen patients (between 49 and 70 years-old) visiting the Cancer Institute of the Sao Paulo State were selected, 7 of whom were diagnosed with colorectal carcinoma. Bacterial detection was performed by qRT-PCR. Although all of the tested bacteria were detected in the majority of the fecal samples, quantitative differences between the Cancer Group and healthy controls were detected only for F. nucleatum and C. difficile. The three tested oral microorganisms were frequently observed, suggesting a need for furthers studies into a potential role for these bacteria during colorectal carcinoma pathogenesis. Despite the small number of patients included in this study, we were able to detect significantly more F. nucleatum and C. difficile inthe Cancer Group patients compared to healthy controls, suggesting a possible role ofthese bacteria in colon carcinogenesis. This finding should be considered whenscreening for colorectal cancer.
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