Phagocytic host defence mechanisms require both normally functioning cells and humoral factors. For example, activated complement components and/or specific immunoglobulin are essential for effective ingestion and killing of bacteria by neutrophils, and complement is especially important early in infection, before specific antibody has been produced. Abnormalities of serum complement have previously been reported in malnutrition, and the present study investigated the levels of serum opsonins in children with protein—energy malnutrition (PEM).Opsonic activity for Escherichia coli and Staphylococcus aureus was depressed in acute PEM patients, but recovered to higher levels with treatment. This depression was detected only when low concentrations of serum (10-20 ml/litre) were used. Marked and persistent opsonin deficiencies were associated with poor clinical response. Reduced opsonic activity may adversely affect host defence mechanisms and contribute to morbidity and mortality from pyogenic infections in PEM. Replacement therapy with fresh or fresh frozen plasma might restore opsonic activity in these patients and reduce the risk of septicaemia and its attendant high mortality.
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机译:吞噬细胞的宿主防御机制需要正常运作的细胞和体液因子。例如,活化的补体成分和/或特异性免疫球蛋白对于嗜中性粒细胞有效摄取和杀死细菌是必不可少的,并且补体在感染早期,在产生特异性抗体之前尤其重要。营养不良曾有血清补体异常的报道,本研究调查了蛋白质-能量营养不良(PEM)患儿的血清调理素水平。急性PEM患者对大肠杆菌和金黄色葡萄球菌的渗透活性降低,但恢复到更高水平的治疗。仅当使用低浓度血清(10-20 ml / L)时才检测到这种抑郁。严重的和持续的调理素缺乏症与不良的临床反应有关。调理活动减少可能对宿主防御机制产生不利影响,并导致PEM化脓性感染的发病率和死亡率增加。新鲜的或新鲜的冷冻血浆替代疗法可能会恢复这些患者的调理活性,并降低败血病的风险和随之而来的高死亡率。
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