Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium

摘要

BackgroundIt was previously shown that K⁺ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane. Receptor activation by uracil nucleotides (P2Y2, P2Y4 or P2Y6) leads to a decrease in the electrogenic K⁺ secretion. The present study was conducted to determine the subtype of the functional purinergic receptor in gerbil stria vascularis, to test if receptor activation leads to elevation of intracellular [Ca²⁺] and to test if the response to these receptors undergoes desensitization.